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Long-Term Effects of 3-Month Telemetric Blood Pressure Intervention in Patients with Inadequately Treated Arterial Hypertension.
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The reductions in blood pressure during the morning period were similar to the mean 24-h blood pressure reduction, suggesting a smooth decrease in blood pressure that was maintained throughout the dosing interval.
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In patients with essential hypertension treated with losartan potassium and hydrochlorothiazide tablets alone, no patients were discontinued due to these laboratory adverse experiences.
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The proportions of patients in each group who reached the primary end point are shown in Figure 2 Cumulative Proportions of Patients with the Primary Composite End Point (Panel A) and Its Components, a Doubling of the Base-Line Serum Creatinine Concentration (Panel B), End-Stage Renal Disease (Panel C), and Death from Any Cause (Panel D).
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Figure 1 and Table 2); this difference was primarily the result of an effect on fatal and nonfatal stroke.
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For many patients, these adverse symptoms disappear shortly after the initial few weeks of taking the drug, but if the problems persist, it may indicate the patient is having issues tolerating the drug, and a new medication may be needed.
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One review of the efficacy and safety of losartan in the treatment of essential hypertension indicated a slowly developing response, with blood pressure becoming lower over several weeks of continued treatment.
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