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The collection of harms was well reported (maximum quality score) and showed higher frequency of nausea for rivastigmine than donepezil during the titration phases.

This analysis included both those who completed the study and those who discontinued their assigned treatment prematurely.

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Donepezil, the most widely used inhibitor for treating symptoms of (AD), was originated and developed by Eisai, a Japanese pharmaceutical company, and Japan was the first country to initiate the clinical development.

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Lanctôt and colleagues (), in a review of 16 cholinesterase trials, also concluded that the mean proportion of global responders in excess of placebo was 9% (CI, 6% to 12%).

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Following a general rule required by the Japanese regulatory authority in those days, Japan independently conducted Phase II dose-finding studies and Phase III confirmatory studies, as well as a study to evaluate the safety of long-term treatment and proved efficacy and safety in Japanese patients.

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In these studies, animals were randomly assigned to receive intrathecal saline, the nicotinic antagonist mecamylamine, 50 μg, or a combination of this dose of mecamylamine and atropine, 3 μg, 30 min after oral donepezil, and withdrawal threshold was determined 30 min later (1 h after donepezil).

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Conduct comparative effectiveness research that includes a cost-effectiveness component to examine community-based interventions, services, and supports to improve health outcomes and quality of life for adults on the ASD spectrum over age 21 by 2018.

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Donepezil is an acetylcholinesterase inhibitor under development for the treatment of mild-moderately Alzheimer's disease.

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