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In 11 patients with reductions in LDL-C, the mean LDL-C changes for the 40- and 80-mg doses were 14% (range 8% to 23%, median 12%) and 30% (range 14% to 46%, median 29%), respectively.

Kids with cholesterol take statins like mom, dad, Debra Sheman.

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Safety and effectiveness of simvastatin in patients 10-17 years of age with heterozygous familial hypercholesterolemia have been evaluated in a controlled clinical trial in adolescent boys and in girls who were at least 1 year post-menarche.

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In contrast, the risk of myopathy may be substantially increased in patients who take 80 mg of simvastatin daily (and some other high-dose statin regimens), as well as in those who are also receiving certain other drugs (e.

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AD suggests that the reduction in incidence of dementia associated with statin use observed in our study also applies to AD, although the exact degree is risk reduction for AD might differ from that observed in our study.

An important secondary outcome was the time to the first exacerbation.

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The Prospective Randomized Placebo-Controlled Trial of Simvastatin in the Prevention of COPD Exacerbations (STATCOPE) was a prospective, multicenter trial conducted by the National Heart, Lung, and Blood Institute (NHLBI) COPD Clinical Research Network to examine the effect of daily treatment with simvastatin for at least 12 months (range, 12 to 36) on the rate of exacerbations among patients with moderate-to-severe COPD and no other indications for statin treatment.

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