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In the two trials described and in several smaller studies involving patients with moderate to severe erosive esophagitis, Lansoprazole produced healing rates similar to those shown above.

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In two other controlled clinical trials of acute otitis media performed in the United States, where significant rates of beta-lactamase producing organisms were found, BIAXIN was compared to an oral antimicrobial agent that contained a specific beta-lactamase inhibitor.

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In postmarketing experience, erythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines.

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There have been postmarketing reports of colchicine toxicity with concomitant use of clarithromycin and colchicine, especially in the elderly, some of which occurred in patients with renal insufficiency.

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